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KMID : 0379520060220040365
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한국독성학회지
2006 Volume.22 No. 4 p.365 ~ p.373
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Effects of Propyl Pyrazole Triol on the Blood Vessel-Dilation and Cellular Morphology of Liver and Kidney in Adult Male Mouse
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Lee Eun-Jung
Lee Yu-Mi
Choi Eun-Sang
Seong Chi-Nam
Cho Hyun-Wook
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Abstract
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The present study was designed to characterize the effects of estrogen receptor agonist (4,4’’,4’’-(4-Propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol, PPT) on liver and kidney in male mouse using a light microscopic analysis. PPT was subcutaneously given to adult male mice at a weekly dosage of 178.6mg/kg in a volume 0.08 ml of vehicle for 3, 5 and 8 weeks. There were differences in body and organ weights between control and the treated groups. Body and kidney weights were decreased in treated group whereas, liver weight was increased. In microscopic observations, sinusoidal diameter in liver of treated group was increased 156%, 216% and 255% on week 3, 5 and 8 respectively. Compared to the control, diameter of proximal convoluted tubules in kidney was increased 37% and 43% or week 5 and 8 in treated group. Whereas, height of epithelial cells in the proximal tubules was reduced at all time points. These results suggest that microstructure of liver and kidney was changed by treatment of estrogen receptor agonist PPT in the male mice.
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KEYWORD
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Estrogen receptor, Propyl pyrazole triol, Liver, Kidney, Male mouse
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